Phosphorylation site prediction
Background
There are two issues remained to be solved:
- To improve accuracy in prediction of phosphorylation sites.
- To further discovery the cognate kinases corresponding to their phosphorylation sites.
There are also two difficulties mentioned by the phosphorylation site prediction:
- To find a standard rule for the protein kinase classification.
- To control/improve the false positive rate (FPR) for the large-scale prediction.
Prediction tools :
| Name | Link | Desc |
|---|---|---|
| GPS 2.0 | link | a tool to predict kinase-specific phosphorylation sites in hierarchy |
| Phopho.ELM | link | a database of experimentally verified phosphorylation sites in eukaryotic proteins |
| ScanSite | link | Proteome-wide prediction of cell signaling interactions using short sequence motifs |
| PhoScan | link | Prediction by log-odds ratio or consensus sequences |